Genome Research and Education Center of SibFU

The Genome Research and Education Center was awarded a 81.6 million rouble (~ $2.6M) grant from the Russian government

The Ministry of Education and Science of Russian Federation announced the names of 42 winners (from the total of 503 applicants) of the fourth competition for research grants under the guidance of leading scientists (Russian Federation Government Resolution № 220) including the project submitted by our Center in the "Agriculture, forestry and fisheries” area:

“Genomics of the key boreal forest conifer species and their major phytopathogens in the Russian Federation”
The PI of the project is Professor Dr. Konstantin V. Krutovsky, the Scientific Director of the Center.

Congratulations to all the researchers of the Center!

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse

The humble horse has provided the oldest full genome sequence of any species — from a specimen more than half a million years old, found frozen in the permafrost of the Canadian Arctic. The finding, published in Nature today, pushes back the known origins of the equine lineage by about 2 million years, and yields a variety of evolutionary insights.
The sequence was extracted from a foot bone of a horse that lived between 780,000 and 560,000 years ago. By sequencing the animal's genome, along with those of a 43,000-year-old horse, five modern domestic horse breeds, a wild Przewalski’s horse and a donkey, researchers were able to trace the evolutionary history of the horse family in unprecedented detail. They estimate that the ancient ancestor of the modern Equus genus, which includes horses, donkeys and zebras, branched off from other animal lineages about 4 million years ago — twice as long ago as scientists had previously thought.

The Norway spruce genome sequence and conifer genome evolution

Conifers have dominated forests for more than 200  million years and are of huge ecological and economic importance. Here we present the draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm. The number of well-supported genes (28,354) is similar to the >100 times smaller genome of Arabidopsis thaliana, and there is no evidence of a recent whole-genome duplication in the gymnosperm lineage. Instead, the large genome size seems to result from the slow and steady accumulation of a diverse set of long-terminal repeat transposable elements, possibly owing to the lack of an efficient elimination mechanism. Comparative sequencing of Pinus sylvestris, Abies sibirica, Juniperus communis, Taxus baccata and Gnetum gnemon reveals that the transposable element diversity is shared among extant conifers. Expression of 24-nucleotide small RNAs, previously implicated in transposable element silencing, is tissue-specific and much lower than in other plants. We further identify numerous long (>10,000 base pairs) introns, gene-like fragments, uncharacterized long non-coding RNAs and short RNAs. This opens up new genomic avenues for conifer forestry and breeding.

International Conference '' High-Throughput Sequencing in Genomics'' (HSG-2013) 21-25 July 2013 Novosibirsk, Russia

International Conference "High-Throughput Sequencing in Genomics", organised by Institute of Chemical Biology and Fundamental Medicine SB RAS cooperatively with the Institute of Molecular and Cellular Biology SB RAS, is devoted to the modern methods of high-throughput DNA sequencing and their applications in different areas of biology.